SYNTHESIS OF 4-1-(4-CYANO PHENYL)-(1,2,4-TR1AZOL-1-YL)METHYL BENZONITRILE AND 4-1-(1H-1,2,4-TRIAZOL-1-YL)METHYLENE BENZONITRILE INTERMEDIATE

摘要

(a) the reaction of a 4-halomethyl benzonitrile with 1 ,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1 ,2,4-triazole-1-yl)methyl] benzonitrile of formula II; and (b) precipitation of 4-[1-(1 ,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent.