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A PROCESS FOR PREPARING OPTICALLY PURE (S,S)-2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYL-2-MORPHOLINOL
A PROCESS FOR PREPARING OPTICALLY PURE (S,S)-2-(3-CHLOROPHENYL)-3,5,5-TRIMETHYL-2-MORPHOLINOL
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机译:制备光学纯的(S,S)-2-(3-氯苯基)-3,5,5-三甲基-2-甲酚的方法
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摘要
The present invention relates to a process for preparing optically enriched (S,S)-hydroxybupropion, or a phannaceutically acceptable salt thereof, comprising: (a) contacting hydroxybupropion with optically pure camphoric acid, tartaric acid, malic acid or mandelic acid; or an optically pure derivative thereof: (b) isolating an optically enriched salt of (S,S)-hydroxybupropion; and (c) contacting the salt of (S,S)-hydroxybupropion with a base.
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