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PHARMACEUTICAL COMPOSITIONS WITH RECEPTOR TYROSINE KINASE INHIBITORS AND ANGIOGENESIS INHIBITORS
PHARMACEUTICAL COMPOSITIONS WITH RECEPTOR TYROSINE KINASE INHIBITORS AND ANGIOGENESIS INHIBITORS
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机译:受体酪氨酸激酶抑制剂和血管生成抑制剂的药物组合物
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摘要
The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of receptor tyrosine kinase antagonists/inhibitors, especially ErbB receptor antagonists, more preferably EGF receptor (Her 1)antagonists and anti-angiogenic agents, preferably integrin antagonists, optionally together with agents or therapy forms that have additive or synergistic efficacy when administered together with said combination of antagonists/inhibitors, such as chemotherapeutic agents and or radiation therapy. The therapy can result in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more affective treatment than found by administering an individual component alone.
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