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A PROCESS FOR THE PREPARATION OF DESGLUCODESRHAMNORUSCIN

机译:脱沙司沙门氏菌素的制备方法

摘要

The present invention relate to a process for the preparing desglucodesrhamnoruscin, which comprises enzymatically hydrolyzing rhamnose-arabinose hetrosidic bond of Ruscus aculeatus steroid glycosides with crude hydrolase extracted from Aspergillus niger in aqueous solution at pH 5 or in water ethanol mixture containing up to 30% by volume of ethanol, at temperature from 20 to 40° C for times from 3 to 7 days by sequentional removal of (3-glucoside residue followed by removal of a-rhamnoside residue to provide a reaction mixture comprising the desglucodesrhamnoruscin which is recovered in a conventional manner.
机译:本发明涉及一种制备去葡萄糖基去甲柔丝霉素的方法,该方法包括用从黑曲霉中提取的粗水解酶在pH 5的水溶液中或在含水乙醇混合物中的水解度最高为30%,该酶水解棘孢类固醇糖苷的鼠李糖-阿拉伯糖异位键。通过依次除去(3-葡萄糖苷残基,然后除去α-鼠李糖苷残基)在20至40°C的温度下,在20至40°C的温度下进行3至7天的时间,以提供一种包含去葡萄糖desrhamnorususcin的反应混合物,该混合物可通过常规方法回收方式。

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