A BLOOD SUBSTITUTE PRODUCT COMPRISING SURFACE-MODIFIED OXYGENATED HEMOGLOBIN

摘要

ABSTRACT 1528/CHENP/2004 "A blood substitute product comprising surface-modified oxygenated hemoglobin" This invention relates to a blood substitute product comprising surface-modified oxygenated hemoglobin, wherein the surface-modified oxygenated hemoglobin is hemoglobin to which polyalkylene oxide has been covalently attached via a surface thiol group of an exposed amino acid side chain on the hemoglobin molecule while the hemoglobin is in the oxygenated state: and wherein the surface-modified oxygenated hemoglobin has a P50 less than native stroma-free hemoglobin from the same animal source when measured under the same conditions.