VACCINE COMPOSITION COMPRISING DIPHTHERIA, TETANUS AND ACELLULAR PERTUSSIS

摘要

The invention provides a booster vaccine composition comprising diphtheria (D), tetanus (T) and acellular pertussis (pa) antigens and an adjuvant, wherein the concentration of D per 0.5 ml dose of bulk vaccine is 1-4 Lf the concentration of T per 0.5 ml dose of bulk vaccine is 2.5 -7.5 Lf, and the Pa component comprises PT (pertussis toxoid), FHA (filamentous hemagglutinin) and pertactin (69K) wherein the concentration of PT per 0,5 ml dose of bulk vaccine is 2-10ug, the concentration of FHA per 0.5 ml dose of bulk vaccine is 2-10ug ; and the concentration of 69K is in the range 0.5ug to 3 ug per 0.5 ml dose of bulk vaccine. The Vaccine maintains an ability to prevent pertussis while showing exceptionally low rectogenicity.