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FACTOR IX ANALOGUES HAVING PROLONGED IN VIVO HALF LIFE.
FACTOR IX ANALOGUES HAVING PROLONGED IN VIVO HALF LIFE.
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机译:因子IX的模拟在体内半衰期已延长。
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摘要
The invention is related to FIX analogues which have an increased circulation time in the blood stream before activation compared to that that of native FIX (and a week after injection to a patient retains at least about 5% of the FIX activity compared to the initial activity peak value reached after injection). The claimed FIX analogues comprise an inserted cysteine residue which has been further modified by conjugation with a chemical group increasing the molecular weight of the FIX analogue.
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