Oral pharmaceutical dosage forms and process for preparing the tablet dosage fixadx and to treat gastrointestinal side effects associated with treatment with NSAID in mammals and man.The use of the dosage form

摘要

An oral pharmaceutical dosage form comprising an acid susceptible proton pump inhibitor and one or more NSAIDs in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of an enteric coating layered tablet, a capsule or a multiple unit tableted dosage form. The multiple unit dosage form are most preferred. The new fixed formulation is especially useful in the treatment of gastrointestinal side-effects associated with NSAID treatment.