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Fungal cell wall degrading lysozyme for use as an inhibitor of dental biofilms
Fungal cell wall degrading lysozyme for use as an inhibitor of dental biofilms
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机译:真菌细胞壁降解溶菌酶用作牙科生物被膜的抑制剂
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摘要
Disclosed is an isolated fungal enzyme having lysozyme activity. Further disclosed is a fungal polypeptide having lysozyme activity and belonging to the GH25 family, wherein the enzyme is selected from the group consisting of (a) a polypeptide comprising an amino acid sequence, which has at least 80% identity with amino acids 1 to 233 of SEQ ID NO:2; (b) a polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide encoded by the lysozyme encoding part of the nucleotide sequence inserted into a plasmid present in strain DSM16084; (c) a polypeptide which is encoded by a nucleotide sequence which hybridizes under high stringency conditions with a polynucleotide probe consisting of the complementary strand of nucleotides 84 to 782 of SEQ ID NO:1; or (d) a fragment of (a), (b) or (c) that has lysozyme activity. Further disclosed is the use of such peptides in the manufacture of a dental composition for inhibiting bio-film formation in a subject.
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机译:公开了具有溶菌酶活性的分离的真菌酶。还公开了一种具有溶菌酶活性并属于GH25家族的真菌多肽,其中所述酶选自(a)包含与1-223位氨基酸具有至少80%同一性的氨基酸序列的多肽。 SEQ ID NO:2的; (b)包含氨基酸序列的多肽,该多肽与插入菌株DSM16084中的质粒的核苷酸序列的溶菌酶编码部分所编码的多肽具有至少80%的同一性; (c)由在高严格条件下与由SEQ ID NO:1的核苷酸84至782的互补链组成的多核苷酸探针杂交的核苷酸序列编码的多肽; (d)具有溶菌酶活性的(a),(b)或(c)的片段。还公开了这种肽在制备用于抑制受试者中生物膜形成的牙科用组合物中的用途。
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