4 - (1R, 3R) - 1 - (3,5 - difluorometil) - 3 - 4 - (2 - ethyl - 4 - isopropyl - 4h-1,2,4-triazole - 4-yl) piperidin-1-yl butyl - 1 - (methylsulfonyl) piperidine as a Modulator of CCR5

摘要

Refers to the compound 4 - ((1R, 3R) - 1 - (3,5 - difluorometil) - 3 - [4 - (2 - ethyl - 4 - isopropyl - 4h-1,2,4-triazole - 4-yl) piperidin-1-yl] butyl] - 1 - (methylsulfonyl) piperidine and Procedure Preparation involves reacting a compound of formula (ii) with a Compound of formula (iii) in the Presence d Appropriate and a triazole, followed by reaction with an organometallic Reagent.It also relates to a Pharmaceutical composition. This Compound is useful in the treatment of diseases mediated by CCR5 (modulator function as chemokine receptor); inflammatory diseases, rheumatoid arthritis, psoriasis, Asthma, allergic rhinitis, among others