A combination of antimitotico and Aurora Kinase Inhibitor as Anticancer agents

摘要

Referring to a Pharmaceutical composition comprising: a) a antimitotico Agent selected from the group consisting of: Taxane paclitaxel, a compound of formula (a), among others.Where the ring and is 5 to 6 members of aryl or heteroaryl FUSED of 5 or 6 members as shown in formula a or C; W is N (R12), where R12 is H, alkyl, Halo, among others; X is n o n - oxide; Z is o, S (= OR) or S (= o) 2; r1 is H, alkyl, Halo, among others; R2 is H, Halo, aryl, among others; R3 Is alkyl, cycloalkyl, heterociclilo, among others; and (b) an inhibitor of Aurora Kinase.As (e), where r is H, CN, cycloalkyl, among others; R1, R2 and R3 are h, aryl, heteroaryl, among others. Preferred compounds are: (i), (ii), (iii), among others. It also relates to a preparation method. This Compound is an inhibitor of cell growth and is useful in the treatment of cancer