Secretariat inhibitors of chromium tetrahydropyridine

摘要

A formula compound (I),Where x is n, CH2; R1 is asphalt SO2 asphalt (C1-C6),-Bitumen SO2 halide (C1-C6),1. Asphalt - (1,1-tetrahydrofluoro 2)Among others, R2 is h, aspha AR is arilo, heterogeneous, arilo is replaced by one or more L1A, L1A is halogen, asphalt, C1, CF3, or - (halogen tar (C1-C6)),L1 is, among other things, halogen-cn-cf3-o-tar (C1-C6),-C (o) - o-asphalt (C1-C6),-Well, n is 0-3, among other things. Favorite compounds: (a)(b)Come in. He also mentioned a preparation procedure and a drug synthesis. These compounds are γ - Secretary inhibitors for the treatment of neurodegenerative diseases, Alzheimer's disease and the inhibition of protein amide deposition in, on or around nerve tissue.