Inhibitors of invertase in vascular diseases and addictive salts without spermatic acid, their preparation procedures and drug synthesis containing such substances

摘要

A formula compound (I),Among them, a is an inhibitor of angiosin converting enzyme with basic separable function; B is a compound with effective function matching a group of non donors; m is the number of acid functions separated from B and N, which is the number of basic functions separated from a; a is the number of formula (II).Wherein R1 is h, or tar (C1-C6);R2 is asphalt (C1-C6) or arilalquilo (C1-C6);R3 means lease (C1-C6) or lease (C1-C6);(I) preferably pyridine glycol, peroxide glycol, pyridine. The most popular compounds are: acid (2S) - 2 - [(3 - [5-oxide-4 - (phenylsulfonyl) - 1,2,5-oxadiazol-3-il] - oxi} - propionil) - amine] - scientific acid (2S, 3a, 7a) - 1 - [(2S) - 2 - [(1s) - 2 - [(1s) - butil] - amine] - propionil] - octahydroAcido (2S) - 2 - [(3 - [5-oxido-4 - (phenylsulfonyl-1,2,5-oxadiazol-3-il] - oxi} - propionil) - amine] - pentanodio acido (2S, 3a, 7a) - 1 - [(2S) - 2 - [(1s) - 1 - (toxic butil] - amine} - propionil] - octahydro-1There are others He also mentioned a way to prepare for drug synthesis. This ingredient is useful in the treatment of hypertension and cardiovascular disease.