New insulated particles of nucleic acid, vectors and host cells, insulated polypeptides and their production methods, the manner of production of high-value chemical compounds and the manner of disgnosing of presence or activity of Corynebacterium diphteri

摘要

Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.