COMPOSITION COMPRISING AN OSTEOGENIC PROTEIN AND A CALCIUM PHOSPHATE IN THE FORM OF A SOLID ROD USABLE FOR INTRAOSSEOUS INJECTION, PROCESS FOR THE PREPARATION AND USE THEREOF

摘要

Osteogemc proteins are delivered via an injectable solid rod or hardenable paste The formulation comprises a calcium phosphate material, an osteogemc protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making injectable pharmaceutical compositions and methods of using the osteogenic compositions to treat bone defects are also disclosed