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СПОСІБ ОТРИМАННЯ ІРБЕСАРТАНУСПОСОБ ПОЛУЧЕНИЯ ИРБЕСАРТАНА
СПОСІБ ОТРИМАННЯ ІРБЕСАРТАНУСПОСОБ ПОЛУЧЕНИЯ ИРБЕСАРТАНА
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机译:制备伊贝沙坦的方法[获得伊贝沙坦的方法
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摘要
The present invention relates to a process for the preparation of irbesartan or its pharmaceutically acceptable salts comprising a synthesis of trityl irbesartan by a reaction of 5-(4-(bromomethyl)biphenyl-2-yl)-l-(triphenylmethyl)tetrazole and 2-n-butyl-4-cyclopentane-2-imidazolin-5-one or a salt therof in an organic solvent in the presence of a phase transfer catalyst and a base, a removal of the protecting group and an isolation of irbesartan or its pharmaceutically acceptable salt.
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