首页> 外国专利> N- (METHYL) -1H- PYRAZOL- 3 -AMINE, N- (METHYL) -PYRIDIN-2-AMINE AND N- (METHYL) -THIAZ0L-2-AMINE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS, LIKE E.G. ALZHEIMER'S

N- (METHYL) -1H- PYRAZOL- 3 -AMINE, N- (METHYL) -PYRIDIN-2-AMINE AND N- (METHYL) -THIAZ0L-2-AMINE DERIVATIVES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS, LIKE E.G. ALZHEIMER'S

机译:N-(甲基)-1H-吡唑-3-胺,N-(甲基)-吡啶-2-胺和N-(甲基)噻唑-2-胺衍生物用于治疗与淀粉样或淀粉样样疾病相关的疾病像EG这样的蛋白质老年痴呆症

摘要

The present invention relates to novel compounds of formula (II) that can be employedin the treatment of a group of disorders and abnormalities associated with amyloidprotein, such as Alzheimer's disease, and of diseases or conditions associatedwith amyloid- like proteins. The compounds of the present invention can alsobe used in the treatment of ocular diseases associated with pathological abnormalities/changesin the tissues of the visual system. The present invention further relates topharmaceutical compositions comprising these compounds and to the use of thesecompounds for the preparation of medicaments for treating, or preventing diseasesor conditions associated with amyloid and/or amyloid- like proteins. A methodof treating or preventing diseases or conditions associated with amyloid and/oramyloid- like proteins is also disclosed.
机译:本发明涉及可以使用的新型式(II)化合物治疗一组与淀粉样蛋白有关的疾病和异常蛋白质,例如阿尔茨海默氏病以及与之相关的疾病或状况带有淀粉样蛋白。本发明的化合物还可以用于治疗与病理异常/改变相关的眼科疾病在视觉系统的组织中。本发明进一步涉及包含这些化合物的药物组合物及其用途用于制备治疗或预防疾病的药物的化合物与淀粉样蛋白和/或淀粉样蛋白有关的疾病。一个方法治疗或预防与淀粉样蛋白和/或还公开了淀粉样蛋白。

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