Preparation of fluoromethyl-2,2,2-trifluoro-1- (trifluoromethyl) ethyl ether

摘要

An improved process for preparing fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) by reacting 1,1,1,3,3,3-hexafluoro-2-propanol with formaldehyde and hydrogen fluoride in the presence of or with the subsequent addition of a solvent capable of selectively extracting sevoflurane.