Derivatives of naftofuran and naftotiofeno as antiproliferative agents of the cancer of pancreas and colon. (Machine-translation by Google Translate, not legally binding)

摘要

Derivatives of benzo [b] naphtho [1,2-d] furan, benzo [b] naphtho [1,2-d] thiophene, 2-arylnaphtho [2,1-b] furan and 2-arylnaphtho [2,1- b] thiophene of general formulas i and ii, where r1, r2, y and z can be different types of atoms, chains and groups usually used in organic chemistry, characterized by their potential antiproliferative capacity; in particular, 3,9-dihydroxybenzo [b] naphtho [1,2-d] furan-5-carbonitrile and 3,9-dihydroxybenzo [b] naphtho [1,2-d] thiophene-5-carbonitrile inhibit the proliferation of human malignant cells of pancreas and colon in values higher than the inhibition caused by gemcitabine and 5-fluorouracil, compounds that are used in the treatment of these two types of tumors respectively. Systems i and ii are synthesized by condensation between a compound with active hydrogens and the corresponding aldehyde in basic medium, followed by a photochemical electrocylic closure under oxidizing conditions to promote the aromatization of the formed product, obtaining the different compounds or possible reduction derivatives or hydrolysis, prodrugs and medications for use in anticancer therapy, by any means available in the clinic. (Machine-translation by Google Translate, not legally binding)