USEFUL HYDROGEL COMPOSITIONS FOR THE PROLONGED RELEASE OF MACROMOLECULES, AND MANUFACTURING PROCEDURES OF THE SAME.

摘要

A process for preparing a homogeneous porous hydrogel for prolonged delivery of medicaments, said process comprising the steps of: (a) forming a polymerizable liquid mixture containing between 60 percent by weight and 90 percent by weight of co-monomers polymerizable, in which at least one of the co-monomers is hydrophilic, between 0.1 percent by weight and 5 percent by weight of a cross-linker, and between 10 percent by weight and 40 weight percent of a liquid diffusion enhancer chosen in the group consisting of tetrahydrofurfuryl alcohol, cyclohexyl alcohol, diethylene glycol, polyethylene glycols, glycerol, acetone, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, glyceryl isopropylidene ether, dioxane, tetrahydrofuran, ethyl acetate, dimethyl sulfoxide, and isopropyl alcohol, which is miscible with the co-monomers, and (b) form a hydrogel useful for release Prolonged macromolecule ion, consisting of a homogeneous copolymer that has pores regularly spaced therethrough, and an equilibrium water content value (EWC) in the range of 35% to 85%.