PROCEDURES FOR TUMORS AND METASTASIS TREATMENT USING A COMBINATION OF ANTIANGIOGENIC THERAPIES AND IMMUNOTHERAPIES.

摘要

Use of an alpha vbeta 3 antagonist selected from the group consisting of a RGD-containing peptide, an anti-alphavbeta3 monoclonal antibody, and an anti-alphavbeta3 receptor monoclonal antibody as an angiogenesis inhibiting agent and an antitumor / antigen fusion protein / cytokine as an antitumor immunotherapeutic agent for the preparation of a pharmaceutical composition intended for the treatment of a tumor cell in a patient, wherein said angiogenesis inhibiting agent and the antitumor immunotherapeutic agent are administered in an amount that inhibits the proliferation of the tumor cell a a patient, wherein said antitumor antigen comprises at least one part that binds to the antigen of an antibody directed towards a tumor antigen.