IMMUNO STIMULANT OLIGONUCLEOTIDES WITH REASONS COMBINED WITH IMPROVED ACTIVITY.

摘要

An immunostimulatory nucleic acid of 14-100 nucleotides in length having a base sequence comprising the formula: 5 '' PX1DCGHX2 3 '' or 5 '' X1DCGHX2P 3 '' in which X1 and X2 are independently any sequence from 0 to 10 bases in length, D is a base other than C, C is cytosine, G is guanine, H is a base other than G and P is a sequence containing CG-rich palindrome of at least 10 bases in length, in which a) H is thymine (T) and X2 is CGTTT or CGTTTT, b) P is completely palindromic, H is T and X2 is selected from the group consisting of CG, CGT, CGTT, CGTTT and CGTTTT and / oc) P includes at least a hypoxanthine (I).