TRIAZOLOPIRIMIDINE DERIVATIVES AS INHIBITORS OF GLUCOGENO-SINTASA-QUINASA 3.

摘要

A compound of formula ** see formula ** an N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A represents phenyl, pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R 1 represents hydrogen; formyl; C1-6 alkylcarbonyl; C1-6 alkyl; C1-6 alkyloxycarbonyl; C1-6 alkyl substituted with formyl, C1-6 alkylcarbonyl, C1-6 alkyloxycarbonyl, C1-6 alkylcarbonyloxy; or C 1-6 alkyloxyC 1-6 alkylcarbonyl optionally substituted with C 1-6 alkyloxycarbonyl; X 1 represents a direct link; - (CH 2) n3- or - (CH 2) n4- X1a-X1b-; where n3 represents an integer with a value of 1, 2, 3 or 4; where n4 represents an integer with a value of 1 or 2; where X1a represents O, C (= O) or NR 5; and where X1B represents a direct bond or C1-2 alkyl; R 2 represents C 3-7 cycloalkyl; phenyl; a monocyclic heterocycle of 4, 5, 6 or 7 members containing at least one heteroatom selected from O, S or N; benzoxazolyl or a radical of the formula wherein -B-C- represents a bivalent radical of the formula ** see formula **