USEFUL BENZOFURAN AND BENZOTIOFEN DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR DISEASE.

摘要

A compound of formula (i) or its pharmaceutically acceptable C 1-6 alkyl salt, solvate or ester, ** see formula ** in which: R 1 and R 2 independently represent H or C 1-3 alkyl ; X represents O, CH2 or a bond (ie, it is absent); X 1 represents: ** see formula ** in which R 6 represents H, C 1-6 alkyl, halogen, -O-C 1-3 alkyl, CF 3; R 6 represents C1-3 alkyl or H-, X 2 is O or S; X 3 is - (CH2) n-CH (R 7) - or CH2-CH = CH- in which n is 0, 1 or 2; R 7 represents H or C 1-6 alkyl and the alkyl chain is optionally interrupted by one or more O atoms; X 4 is S or O; R 3 represents H or C 1-6 alkyl; R 4 represents H, CF3, C1-6 alkyl, halogen or O-C1-3 alkyl; and is 0, 1, 2, 3 or 4.