Azaquinazolinas substituted with antiviral action.

摘要

Ar represents aryl, and aryl may be substituted with 1 to 3 substituents, the substituents being independently selected from the group consisting of alkyl, alkoxy, formyl, hydroxycarbonyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxy, amino, alkylamino, aminocarbonyl and nitro, alkyl may be substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, amino, alkylamino, hydroxy and aryl, or two of the aryl substituents together with the carbon atoms to which they are attached they form a 1,3-dioxolane, a cyclopentane ring or a cyclohexane ring and a third substituent, where appropriate, is independently selected from the group mentioned, Q 1, Q 2, Q 3 and Q 4 represent CH or N, representing one or two of Q 1, Q 2, Q 3 and Q 4 N and representing the others at the same time CH, R 1 represents hydrogen, amino, alkyl, alkoxy, alkyl amino, alkylthio, cyano, halogen, nitro or trifluoromethyl, R 2 represents hydrogen, alkyl, alkoxy, alkylthio, cyano, halogen, nitro or trifluoromethyl, R 3 represents amino, alkyl, alkoxy, alkylamino, alkylthio, cyano, halogen, nitro, trifluoromethyl, alkylsulfonyl or alkylaminosulfonyl or one of the moieties R 1, R 2 and R 3 represents hydrogen, alkyl, alkoxy, cyano, halogen, nitro or trifluoromethyl and the other two form together with the carbon atoms to which a 1 is attached , 3-dioxolane, a cyclopentane ring or a cyclohexane ring, R 4 represents hydrogen or alkyl, R 5 represents hydrogen or alkyl or the R 4 and R 5 moieties in the piperazine ring are attached at exactly opposite carbon atoms and form a substituted methylene bridge if necessary with 1 to 2 methyl groups, R 6 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, hydroxycarbonyl, aminocarbonyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hyd roxy or nitro and R 7 represents hydrogen, alkyl, alkoxy, alkylthio, formyl, hydroxycarbonyl, alkylcarbonyl, alkoxycarbonyl, trifluoromethyl, halogen, cyano, hydroxy or nitro, or one of its salts, its solvates or the solvates of its salts.