FACTOR INVOLVED IN THE METASTASIS AND USES OF THE SAME.

摘要

In vitro use of a polypeptide factor or one of its fragments, where the fragment has the effects of polypeptide factor in terms of wound healing, tumor growth, tumorigenesis, metastasis, cell migration, cell motility in an extracellular matrix and growth of cells in an extracellular matrix, wherein said factor: a) comprises an amino acid sequence according to SEQ ID NO. one; b) it has an amino acid sequence according to the data bank entries gi 9506687 or NP_061931.1; c) is encoded by a nucleic acid, wherein: ca) the nucleic acid comprises: i) a nucleic acid according to SEQ ID NO. 2nd SEQ ID NO. 3; or ii) a nucleic acid sequence according to the data bank entries gi 9506686 or NM_019058.1; cb) the nucleic acid encodes the factor as for a) or b) and where the nucleic acid would hybridize, except for the degeneracy of the genetic code, with a nucleic acid according to ca); or cc) the nucleic acid encodes the factor as for a) or b) and wherein the nucleic acid hybridizes under restrictive conditions with a nucleic acid that is complementary to the nucleic acid according to ca); as a target in the 3 '' direction or a marker in the 3 '' direction of the PI 3-kinase pathway, preferably as a drug target in the 3 '' direction of the PI 3-kinase pathway, in scrutiny of drugs, drug design and drug development, where the drug is useful for wound healing, tumor growth inhibition, tumorigenesis, metastasis, cell migration, cell motility in an extracellular matrix and cell growth in an extracellular matrix .