Restoration of hla class i molecules through gene therapy using adenoviral vectors carrying the beta 2-microglobulin gene. (Machine-translation by Google Translate, not legally binding)

摘要

The invention relates to the recovery of the antigenic presentation capacity of tumors in vivo by means of. The restoration of the expression of hla class i molecules using adenoviral vectors. The same will be done in those tumors totally negative for the expression of hla class i molecules due to alterations in the b2-microglobulin, implying the previous diagnosis of the alteration present in the tumor. (Machine-translation by Google Translate, not legally binding)