DERIVATIVES OF TRIAZOLO 4,5-D PYRIMIDINE AND ITS USE AS AN ANTAGONIST OF THE PURINERGIC RECEIVER.

摘要

The use of a compound of the formula (I): ** (See formula) ** where R1 is selected from H, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, halogen, CN, NR5R6, NR4COR5, NR4CONR5 R6, NR4CO2R7 and NR4SO2R7; R2 is selected from aryl radicals linked by an unsaturated carbon; R3 is chosen from H, alkyl, COR5, CO2R7, CONR5R6, CONR4NR5R6 and SO2R7; R4, R5 and R6 are independently selected from H, alkyl and aryl, or when R5 and R6 are in a group NR5R6, R5 and R6 can be linked together forming a heterocyclic group, or if R4, R5 and R6 are in a group (CONR4NR5R6 ), R4 and R5 may be linked forming a heterocyclic group; and R7 is chosen from alkyl and aryl, when any of the radicals R1 to R7 is chosen from alkyl, alkoxy and thioalkyl, this alkyl group or the alkyl group of the alkoxy or thioalkyl group may be substituted or not, and when any of the radicals R1 to R7 is chosen from aryl, aryloxy and thioaryl, said aryl group or the aryl group of the aryloxy or thioaryl group can be substituted or not, and when R5 and R6, or R4 and R5, are joined forming a heterocyclic group, this can be substituted or not, and the substituents are chosen from alkyl, aryl, arylalkyl; halogen, haloalkyl, haloaryl atoms; oxygen carrying groups selected from hydroxy, hydroxyalkyl, hydroxyaryl, (aryl) (hydroxy) alkyl, alkoxy, aryloxy, alkoxyalkyl, aryloxyalkyl, alkoxyaryl, aryloxyaryl, carboxaldehyde, alkylcarbonyl, arylcarbonyl, alkylcarbonylalkyl, alkylcarbonylalkylcarbonylalkylcarbonylalkylcarbonylalkylcarbonylalkyl nilalquilo, arylalkylcarbonylaryl, carboxy, carboxyalkyl, carboxyaryl, alkoxycarbonyl, aryloxycarbonyl, alco-xicarbonilalquilo, aryloxycarbonylalkyl, alkoxycarbonylaryl, aryloxycarbonylaryl, alkylcarbonyloxy, alquilcarbo-niloxialquilo, aminocarbonyl, mono- or di-alkyl-aminocarbonyl, cyclic aminocarbonyl, aminocarbonyl, mono- or di -alkylaminocarbonylalkyl, arylaminocarbonyl or arylalkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino or arylalkylcarbonylamino, alkoxycarbonylamino, aryloxycarbonylamino, arylalkylcarbonylamino, aminocarbonyloxy, mono- or di-alkylaminocarbonyloxy, aryl xi or arylalkylaminocarbonyloxy, mono- or di-alkylaminocarbonylamino, arylaminocarbonylamino or arylalkyl aminocarbonylamino; nitrogen carrying groups selected from amino, mono- or dialkylamino, cyclic amino, arylamino, aminoalkyl, mono- or di-alkylaminoalkyl, azides, cyano, cyanoalkyl, nitro, aminosulfonyl, mono- or di-alkylamino-sulfonyl, mono- or di -arylaminosulfonyl, alkyl- or aryl-sulfonylamino, alkyl- or aryl-sulfonyl (alkyl) -amino, alkyl- or aryl-sulfonyl (aryl) amino; sulfur-bearing groups selected from alkylthio, alkylsulfinyl, alkylsulfonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, arylthio, arylsulfinyl, arylsulfonyl, arylthioalkyl, arylsulfinylalkyl, arylsul-fonylalkyl; and heterocyclic groups selected from thienyl, furanyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, aziridinyl, azetidinyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, tetrahydrofuranyl, pyranyl, pyronyl, pyridyl, pyrazinyl, pyridazinyl , piperidyl, hexahydroazepinyl, piperazinyl, morpholinyl, thianaphthyl, benzofuranyl, isobenzofuranyl, indolyl, oxyindolyl, isoindolyl, indazolyl, indolinyl, 7-azaindolyl, benzopyranyl, coumarinyl, isocoumarinyl, quinolinyl, isoquinolinyl, naphthridinyl, cinnolinyl, quinazolinyl, pyridopyridyl, benzoxazinyl, quinoxalinyl , chromenyl, chromanyl, isochromanyl, phthalazinyl and carbolinyl, where the alkyl groups are selected from cyclic C3 to C12 hydrocarbyl radicals and C1 to C10 acyclic, branched and linear, saturated and unsaturated;