ACILO AND SULFONYL DERIVATIVES OF 2- (TRANS-1,4-DIAMINOCICLOHEXIL) -PURINS 6,9-DISUSTITUTED AND ITS USE AS ANTIPROLIFERATIVE AGENTS.

摘要

A compound according to formula (I) ** see formula ** in which Z is selected from the group consisting of -S (O) 2- and -C (O) -, when Z is -S (O) 2- , R a is selected from the group consisting of -R1 and -N (R1) (R3), or when Z is -C (O) -, R a is selected from the group consisting of -R1, -OR1, -N (R1) (R3) and -SR1, where R1 is selected from the group consisting of -C1-C11 alkyl, where each carbon can be optionally substituted with one, two or three substituents X, -C3-C10 cycloalkyl, where each carbon it may be optionally substituted with one or two substituents X, - (CH 2) nQ p (CH 2) nW, where each carbon of - (CH 2) n- may be optionally substituted with one or two substituents X, Q is O, S, or NR3, n is independently an integer from 0-6, p is independently an integer 0 or 1, W is independently selected from the group consisting of hydrogen, C 3 -C 10 cycloalkyl, - (C3-C10 cycloalkyl ) -aromatic, and one of the following aromatic rings or heteroarom Attics: ** see formula ** where B is -O-, -S-, -NR6-, where each carbon of the aromatic or heteroaromatic ring can be independently substituted by a nitrogen atom, and each carbon of the aromatic ring can be independently substituted with an X substituent; and - (CH2) nCHW2, where each substituent X is independently selected from the group consisting of hydrogen, halogen, methylenedioxy, C 1 -C 8 alkyl, C 3-C 10 cycloalkyl, substituted or unsubstituted phenyl, -C 1-C alkoxy 8, -SR3, -OH, = O, -CY 3, -OCY 3, -CO 2R3, -CN, -CO-NR4R5, -NO 2, -COR3, -NR4R5, -NH-C (O) -R3 , -NH-C (O) - (C 1 -C 6 alkyl) -aromatic, and -NH-C (O) - (C1-C6 alkyl) -heteroaromatic; where each Y is independently selected from the group consisting of hydrogen and halogen; where each R3 is independently selected from the group consisting of hydrogen, and C1-C8 alkyl, where C1-C8 alkyl can be linear or branched, saturated or unsaturated; where each R4 and R5 is independently selected from the group consisting of hydrogen, and C1-C6 alkyl, where C1-C6 alkyl can be linear or branched, saturated or unsaturated, where each C1-C6 alkyl carbon is optionally substituted. with a substituent X, or where R4 and R5 taken together with the nitrogen to which they are attached, form a heterocyclic ring of three to seven atoms including the nitrogen atom; where -NR6- is selected from the group consisting of an unsubstituted N, an N substituted with -hydrogen, - (C1-C6 alkyl), -C3-C10 cycloalkyl, -S (O) 2- (C1-C6 alkyl), -S (O) 2- (C3-C10 cycloalkyl), -C (O) R3, -C (O) - (C0-C6 alkyl) aromatic, and -S (O) 2- (C0-C6 alkyl) - aromatic, where each carbon of the aromatic ring may be optionally substituted with an X substituent; and where the phenyl is substituted with one to five substituents independently selected from the group consisting of hydrogen, halogen, methylenedioxy, -C1-C8 alkyl, -C3-C10 cycloalkyl, -C1-C8 alkoxy, -OH, -CY3, -OCY3 , -CO2R3, -CN, -NO2, -COR3, -NR4R5, -SR3, -CO-NR4R5, and -NH-C (O) -R3; and R2 is selected from the group consisting of cyclopentyl, cyclopentenyl, and isopropyl; or one of its pharmaceutically acceptable salts, optical isomers, solvates or hydrates.