EXPRESSION VECTORS WHICH INCLUDE THE HUMAN PKLR GENE PROMOTER AND USE THEREOF FOR PREPARING PHARMACEUTICAL COMPOSITIONS FOR SOMATIC GENETIC THERAPY WITH SPECIFIC EXPRESSION IN ERYTHROID CELLS

摘要

Expression vectors which include the human PKLR promoter gene and use thereof for preparing pharmaceutical compositions for somatic genetic therapy with specific expression in erythroid cells. The present invention concerns the use of regulatory sequences of the promoter of the PKLR gene in the production of vectors, with the exception of vectors comprising adeno-associated viruses, for use in the preparation of pharmaceutical compositions intended for somatic genetic therapy in erythroid tissue.