Process for the deacylation of cyclic lipopeptides.

摘要

Provides a lipopeptide acylase CYCLIC IS CAPABLE OF deacylating side chain acyl COMPOUND lipopeptide CICLICO, FOR EXAMPLE, THE SUBSTANCE FR901379 the following general formula [II] EFFECTIVELY AS WELL AS A METHOD FOR PRODUCING A peptidic compound CICLICO comprising the use of the acylase. [Wherein R1 is acyl; R 2 is hydroxy or oxyacyl; R 3 is hydrogen or hydroxy; SUP R 4 is hydrogen or hydroxy; R 5 is hydrogen U OXIHIDRO XISULFONILO; YR 6 is hydrogen or carbamoyl].