INHERITED AND SOMATIC MUTATIONS OF APC GENE IN COLERECTAL CANCER OF HUMANS

摘要

A human gene termed APC is disclosed. Methods and kits are providedfor assessing mutations of the APC gene in human tissues and body samples.APC mutations are found in familial adenomatous polyposis patients as wellas in sporadic colorectal cancer patients. APC is expressed in most normaltissues. These results suggest that APC is a tumor suppressor.