METHOD FOR SPECIFICALLY DETECTING A COAGULATION FACTOR V WHICH HAS AN INCREASED STABILITY TOWARD ACTIVATED PROTEIN C IN THE ACTIVATED STATE

摘要

The invention relates to a method for qualitative detection and quantitative determination of the stability of activated coagulation factor V towards proteolytic degradation in a biological fluid sample, which includes mixing the sample with reagent A whose content of functional factor V is diminished as compared with normal, human plasma, adding a reagent B for activating the factor V of the sample, adding a reagent C for proteolytically degrading the activated factor V of the sample and adding reagents for determining residual factor Va activity. The sample forms at most 20% (pref. = 10%) of the total test vol.