HUMAN COMPLEMENTARITY DETERMINING REGION (CDR) - GRAFTED ANTIBODY TO GANGLIOSIDE GM2

摘要

A human CDR-grafted antibody which specifically reacts with ganglioside CM2, wherein said antibody comprises CDR 1, CDR 2 and CDR 3 of heavy chain (H chain) variable region (V region) comprising amino acid sequences described in SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and CDR 1, CDR 2 and CDR 3 of light chain (L chain) V region comprising amino acid sequences described in SEQ ID NO:4, SEQ ID NO: 5 and SEQ ID NO:6, and wherein at least one of the frameworks (FR) of said H chain and L chain V regions comprises an amino acid sequence selected from common sequences (HMECS; human most homologous consensus sequence) derived from human antibody subgroups.