ANTIBACTERIAL AQUEOUS OPHTHALMIC FORMULATIONS CONTAINING OFLOXACIN AND USE OF CHITOSAN FOR SOLUBILIZING OFLOXACIN SUSPENDED IN AN AQUEOUS MEDIA

摘要

The aqueous ophthalmic formulation for the treatment and prevention of infections contains ofloxacin as active ingredient and a chitosan having a weight average molecular weight of 500,000 - 5,000,000 Daltons and a deacetylation degree of 30 - 90 % as solubilizing agent of ofloxacin. Chitosan having a deacetylation degree of 30 - 90 % may be also used for solubilizing ofloxacin suspended in an aqueous media having a substantially neutral pH in any other applications.