RENOPROTECTION BY GROWTH HORMONE-RELEASING HORMONE AND AGONISTS

摘要

In the present study, regulation of renal and pituitary GHRH-R mRNA levels wasexamined using in vivo models of NaCl or water homeostasis disruption. Thepresence of a unique GHRH/GHRH-R system in Henle's loop ascending thin limbcelland the specific regulation of GHRH-R mRNA levels and GHRH sensitivity in asituation of hyperosmotic stress, together with the strong effect of GHRH onmitochondrial and nuclear DNA repair/synthesis, indicate a role for GHRH inrenoprotection. GHRH appears to be involved in adaptive processes related toDNArepair and/or synthesis thereby protecting ascending limb cell function insubjectswith renal vulnerability (aging, diabetes) and were a health event could leadto aproduction of oxidative stress (antibiotic toxicity, cancer chemotherapeuticagenttoxicity, infection, inflammation, ischemia ) and renal failure.