AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES, NOVEL PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES

摘要

The present invention relates tonovel amidine, thiourea and guanidine derivativesof appropriately substituted 2-aminobenzothiazoles,2-amino-3,1-4H-benzothiazines and 3-amino-1,4-3H-benzothiazines, as understood fromformula (I), the related pharmaceutically acceptablesalts and solvates thereof: Formula (I): and the use ofsaid products and the corresponding pharmaceuticalformulations for the treatment of neurodegenerativepathologies such as cerebral ischemia, neurodegenerationinduced by cranial trauma, Alzheimer's disease, Multiple Sclerosis andAmyotrophic Lateral Sclerosis.