ACTIVATORS OF TUMOR SUPPRESSOR PROTEIN P53 PATHWAY AND THERAPEUTIC APPLICATIONS THEREOF

摘要

The invention presents methods of identifying small molecule compounds thatare activatorsof tumor suppressor protein p53 pathway, and its associated family members p63and p73,function. The invention is further drawn to methods of killing tumor cells andtreatingcancers or other conditions requiring activation of the p53 family memberpathways and DNAdamage response pathways with the small molecules.