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Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic escherichia coli infections
Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic escherichia coli infections
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机译:制备用于治疗,预防或抑制肠毒素性大肠杆菌感染的CS6抗原疫苗的方法
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摘要
Disclosed herein are methods for making large amounts of highly pure colonization factors. The methods of the present invention differ from prior art methods in that host cells which express the colonization factor of interest are cultured in media comprising more than about 50 mug/l of an antibiotic, the media is centrifuged and then filtered with a 0.2 mum filter tangential flow cartridge and a 300,000 MW cut-off filter, and a divalent cation is added. As disclosed herein the colonization factors made by the method of the present invention may be used in pharmaceutical compositions and methods for treating or preventing enterotoxigenic Escherichia coli infections.
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