Galenic formulation for colon targeted delivery of active principles

摘要

Orally administrable multiparticular formulation for intestinal delivery of active agents, comprises pectin granules in the form of a cationic salt containing the active agent, where the pectin is crosslinked with a cationic polymer. An independent claim is also included for the preparation of the multiparticular formulation comprising mixing an aqueous solution containing the pectin and active agent with an aqueous solution of a cationic salt to form pectin granules in the form of a cationic salt, followed by addition of an aqueous solution of a cationic polymer to form crosslinked granules.