A SYSTEM AND METHOD OF ADMINISTERING A THERAPEUTIC MATERIAL TO BRAIN TISSUE

摘要

A system and method employing intraparenchymal pressure-driven delivery of a treatment material into brain tissue at risk for infiltrating tumor cells is provided. The system and method employ bulk flow as a driving force, by creating a positive pressure gradient using a pump. The pump is connected to an infusion catheter placed directly into brain parenchyma to be treated. The positive pressure is transmitted through this delivery system into the interstitial space of the brain parenchyma. Catheter positioning relative to anatomic landmarks and structures in the targeted tissue region plays a key role in optimizing the pressure-driven delivery of treatment material into the interstitial space.