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METHODS FOR INHIBITION OF LYMPHANGIOGENESIS AND TUMOR METASTASIS
METHODS FOR INHIBITION OF LYMPHANGIOGENESIS AND TUMOR METASTASIS
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机译:抑制淋巴管生成和肿瘤转移的方法
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摘要
The present invention is directed to compositions and methods for inhibiting the development of new lymphatic vessels, and for inhibiting tumor cell dissemination through the lymphatics. In preferred embodiments, the present invention utilizes agents that inhibit the specific binding of integrin alpha4beta1 (a4ßl, VLA-4) to one or more of its ligands. The invention further relates to methods for screening test compounds for their ability to inhibit undesirable lymphangiogenesis and/or tumor metastasis.
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