FULLY-AUTOMATED MICROFLUIDIC SYSTEM FOR THE SYNTHESIS OF RADIOLABELED BIOMARKERS FOR POSITRON EMISSION TOMOGRAPHY

摘要

The present application relates to microf luidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses, a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and method of using such instruments. The systems comprise a microfluidic synthesis chip comprising a reagent source, a controller, a reaction chamber, a membrane, at least one flow channel and at least one valve (260, 265). The systems may additionally comprise radiation shielding and heating or cooling elements (270).