18F FLUORO-BENZOYL LABELLED BIOLOGICAL ACTIVE COUMPOUNDS AS DIAGNOSITIC IMAGING AGENTS AS WELL AS BENZOTRIAZOL-1-YLOXY-BENZOYL, 2,5-DIOXO-PYRROLIDIN-1-YLOXY) BENZOYL AND TRIMETHYLAMMONIO-BENZOYL PRECURSERS

摘要

The present invention relates to radiolabelled substitute benzene compounds for diagnostic imaging. The present invention provides methods for preparation of such compounds, in particular, preparation of novel compounds which serve as precursors for 18F-labeling, and the use of thus 18F-labe!ed compounds for diagnostic imaging. Formula (A), wherein one of -Y1, -Y2, -Y3 Y4 and -Y5 is -A-B-D-P, wherein -A-B-D- is a bond or spacer, P is peptide, peptidomimetic, oligonucleotide or small molecule. K is LG-O or W, wherein: LG- is selected from the group comprising Formula (B), wherein T is H or Cl, Q is CH or N, K is absent or is C=O. W is radioactive or non-radioactive isotope of fluorine, more preferably 18F.