METHODS FOR MONITORING DISEASE PROGRESSION OF ALZHEIMER'S DISEASE USING CSF MARKERS FROM LONGITUDINAL SAMPLES

摘要

The present invention provides a means for monitoring the progression of Alzheimer s disease (AD) in an AD patient. The method comprises the construction of an AD progression panel selected from a plurality of markers that have been identified from fluid samples of AD patients to be statistically significant and differentially expressed over time. The method employs the use of a linear mixed effects model to assess the progression over time of each marker in an AD patient. The first selected set of AD progression markers changes over time in AD patients. A preferred subset of this set of AD progression markers also shows a rate of change that is significantly different between AD patients and control subjects. An alternative set of AD progression markers shows statistically significant change with progression in AD patients, where progression is measured by the changes in cognitive scores.