首页>
外国专利>
MODULATORS OF VEGF SPLICING AS PRO- AND ANTI-ANGIOGENIC AGENTS
MODULATORS OF VEGF SPLICING AS PRO- AND ANTI-ANGIOGENIC AGENTS
展开▼
机译:血管内皮生长因子剪接调节剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favours proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favours distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
展开▼