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NEW PROCESS FOR THE SYNTHESIS OF LOFERPRAMINE MALEATE: A STABLE SALT OF LOFERPRAMINE
NEW PROCESS FOR THE SYNTHESIS OF LOFERPRAMINE MALEATE: A STABLE SALT OF LOFERPRAMINE
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机译:合成乐法拉定的新方法:稳定的乐法拉定盐
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摘要
This invention relates to a stable salt of Lofepramine and A process for the synthesis of stable Lofepramine maleate comprising; dissolving maleic acid in ethyl acetate by warming and the solution is then filtered hot; adding purified Lofepramine base to the said clear solution of maleic acid and heated upto about 40-60°C; filtering the precipitates of Lofepramine maleate; drying the said precipitates at 45 to 55°C to obtain Lofepramine maleate.
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