NOVEL FACULTATIVE CATONIC STEROLS

摘要

A facultative cationic sterol derivate, said sterol derivate has a pka value of between 3.5 and 8 and the general formula Cation-Spacer 2-Y-Spacer 1-X-Sterol wherein X and Y are linking groups and wherein at least on of X and Y is -NH(C=O)-O- and/or -O-(C=O)-NH. Also disclosed are liposomes comprising said sterol derivatives.