METHODS FOR MODULATING OSTEOBLAST CELL DIFFERENTIATION AND BONE GENERATION THROUGH INHIBITION OF A PROLYL HYDROXYLASE

摘要

The present invention provides compositions comprising inhibitors of prolyl hydroxylase(s), and methods of using the compositions to promote bone healing, improve bone mass or volume, promote osteoblast cellular differentiation, and/or promote osteogenesis. The compositions of the present invention also may be used in the treatment of various bone-loss or bone density decreasing disorders. The present invention further provides a screening tool for the determination of additional compounds capable of promoting bone healing, promoting osteoblast cellular differentiation, improving bone mass or volume, and/or promoting osteogenesis.