USE OF INHIBITION OF EXONUCLEASE 1 IN METHODS FOR THERAPY AND DIAGNOSTIC OF NEURODEGENERATIVE DISEASES, EYE DISEASES, AND MITOCHONDRIAL DISORDERS

摘要

The present invention relates generally to methods and compositions for the diagnosis and treatment and/or prevention of neurodegenerative diseases, mitochondrial disorders, and eye diseases. In particular, the present invention relates to methods and compositions for the treatment and/or prevention of neurodegenerative diseases, retinal diseases or mitochondrial disorders using at least one agent that inhibits the expression and/or activity of EXO1 protein.